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Add CL:9900001 AVPV/PeN kisspeptin neuron#3624

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Add CL:9900001 AVPV/PeN kisspeptin neuron#3624
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Copilot AI commented Apr 30, 2026 •
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  • Add new term CL:9900001 (AVPV/PeN kisspeptin neuron) to cl-edit.owl
    • Add Declaration stanzas (CL_9900001, PR_P19785, PR_Q6Y4S4, UBERON_0002690, UBERON_0002708)
    • Add full class definition with annotations, synonyms, SubClassOf axioms
    • Add in-text parenthetical author references in the definition text
    • Validate ontology syntax with robot convert

Copilot AI linked an issue Apr 30, 2026 that may be closed by this pull request
[NTR] AVPV/PeN kisspeptin neuron #3623
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Add CL:9900001 AVPV/PeN kisspeptin neuron (issue #3623)
ecb80ca 
New term for the AVPV/PeN kisspeptin neuron population found in the
anteroventral periventricular nucleus (UBERON:0002690) and posterior
periventricular nucleus (UBERON:0002708).

Term details:
- Label: AVPV/PeN kisspeptin neuron
- Parent: CL:4023123 (hypothalamus kisspeptin neuron)
- Synonyms: anteroventral periventricular nucleus kisspeptin neuron,
  AVPV Kiss1 neuron (exact); AVPV kisspeptin neuron, PeN Kiss1 neuron,
  PeN kisspeptin neuron (related)
- Soma locations: UBERON:0002690 (AVPV), UBERON:0002708 (PeN)
- Capable of: GABA secretion (GO:0061534), dopamine secretion (GO:0061527)
- Expresses: Kiss1/KiSS-1 (PR:Q6Y4S4), TH (PR:P24529), ERalpha (PR:P19785)
- Contributor ORCID: 0000-0002-5507-2103
- References: PMID:28660243, PMID:17213691, PMID:29201072, PMID:17699664,
  PMID:23407940, PMID:37934722

Signed-off-by: GitHub Copilot

Agent-Logs-Url: https://github.com/obophenotype/cell-ontology/sessions/c023447a-1e8d-4fb3-8c23-dd904a06a986

Co-authored-by: RiveraAndrea83 <205639972+RiveraAndrea83@users.noreply.github.com>
Copilot AI changed the title [WIP] Add AVPV/PeN kisspeptin neuron term Add CL:9900001 AVPV/PeN kisspeptin neuron Apr 30, 2026
Copilot AI requested a review from RiveraAndrea83 April 30, 2026 11:54
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RiveraAndrea83 commented Apr 30, 2026

#gogoeditdiff

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RiveraAndrea83 commented Apr 30, 2026

@copilot: please add back the in-text references in the definition.

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Add in-text references to CL:9900001 definition
2d3a25c 
Restore parenthetical author citations throughout the definition text,
matching the references provided in the original NTR. Also adds PMID:34561233
(Wartenberg et al., 2021) to the definition xrefs for the ERalpha sentence.

Signed-off-by: GitHub Copilot

Agent-Logs-Url: https://github.com/obophenotype/cell-ontology/sessions/5d0d3c1f-f291-4d28-bcb6-ea37010c32e0

Co-authored-by: RiveraAndrea83 <205639972+RiveraAndrea83@users.noreply.github.com>
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Copilot AI commented Apr 30, 2026

@copilot: please add back the in-text references in the definition.

Done in commit 2d3a25c. The definition now includes in-text parenthetical references throughout: (Stephens et al., 2017; Nejad et al., 2017) for soma location, (Adachi et al., 2007; Nejad et al., 2017) for LH surge, (Stephens et al., 2017; Kauffman et al., 2007; Stephens et al., 2024) for co-expression identity, (Frazao et al., 2013; Wartenberg et al., 2021) for ERalpha, and (Stephens et al., 2024) for distinction from KNDy neurons. PMID:34561233 (Wartenberg et al., 2021) was also added to the definition xrefs.

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github-actions Bot commented Apr 30, 2026 •
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Here's a diff of how these changes impact the classified ontology (on -base file):

Ontology comparison

Left

  • Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
  • Version IRI: http://purl.obolibrary.org/obo/cl/releases/2026-05-01/cl-base.owl
  • Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-master.owl/cl-base.owl

Right

  • Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
  • Version IRI: http://purl.obolibrary.org/obo/cl/releases/2026-05-01/cl-base.owl
  • Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-pr.owl/cl-base.owl

Ontology imports

Ontology annotations

AVPV/PeN kisspeptin neuron http://purl.obolibrary.org/obo/CL_9900001

Added

In mice, it co-expresses kisspeptin (Kiss1) and tyrosine hydroxylase (TH), indicating a dopaminergic component within an otherwise primarily GABAergic phenotype (Kauffman et al., 2007; Stephens et al., 2017, 2024). It also expresses estrogen receptor alpha (Esr1), enabling direct regulation by estradiol (Frazao et al., 2013; Wartenberg et al., 2021).

It belongs to a sexually dimorphic population, with higher cell numbers observed in females than in males in rodents (Stephens et al., 2017; Nejad et al., 2017)."

PR_P19785 http://purl.obolibrary.org/obo/PR_P19785

Added

PR_Q6Y4S4 http://purl.obolibrary.org/obo/PR_Q6Y4S4

Added

UBERON_0002690 http://purl.obolibrary.org/obo/UBERON_0002690

Added

UBERON_0002708 http://purl.obolibrary.org/obo/UBERON_0002708

Added

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github-actions Bot commented Apr 30, 2026 •
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Here's a diff of your edit file (unreasoned)

Ontology comparison

Left

  • Ontology IRI: http://purl.obolibrary.org/obo/cl.owl
  • Version IRI: None
  • Loaded from: file:/__w/cell-ontology/cell-ontology/master/src/ontology/cl-edit.owl

Right

  • Ontology IRI: http://purl.obolibrary.org/obo/cl.owl
  • Version IRI: None
  • Loaded from: file:/__w/cell-ontology/cell-ontology/branch/src/ontology/cl-edit.owl

Ontology imports

Ontology annotations

AVPV/PeN kisspeptin neuron http://purl.obolibrary.org/obo/CL_9900001

Added

In mice, it co-expresses kisspeptin (Kiss1) and tyrosine hydroxylase (TH), indicating a dopaminergic component within an otherwise primarily GABAergic phenotype (Kauffman et al., 2007; Stephens et al., 2017, 2024). It also expresses estrogen receptor alpha (Esr1), enabling direct regulation by estradiol (Frazao et al., 2013; Wartenberg et al., 2021).

It belongs to a sexually dimorphic population, with higher cell numbers observed in females than in males in rodents (Stephens et al., 2017; Nejad et al., 2017)."

anteroventral periventricular nucleus http://purl.obolibrary.org/obo/UBERON_0002690

Added

estrogen receptor (mouse) http://purl.obolibrary.org/obo/PR_P19785

Added

metastasis-suppressor KiSS-1 (mouse) http://purl.obolibrary.org/obo/PR_Q6Y4S4

Added

posterior periventricular nucleus http://purl.obolibrary.org/obo/UBERON_0002708

Added

dosumis
dosumis previously approved these changes Apr 30, 2026
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Check species specificity & record with in_taxon - If mouse specific then uniprot mouse terms are fine.

@RiveraAndrea83 RiveraAndrea83 marked this pull request as ready for review May 1, 2026 09:45
@RiveraAndrea83 RiveraAndrea83 requested a review from dosumis May 1, 2026 09:46
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dosumis commented May 1, 2026

#gogoeditdiff

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[NTR] AVPV/PeN kisspeptin neuron

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